Publications
- 2023
- AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.
Asteriti IA, Polverino F, Stagni V, Sterbini V, Ascanelli C, Naso FD, Mastrangelo A, Rosa A, Paiardini A, Lindon C, Guarguaglini G.
Life Sci Alliance. 2023 Feb 16;6(5):e202201726. doi: 10.26508/lsa.202201726. PMID: 36797043; PMCID: PMC9936162.More - Aurora B SUMOylation is restricted to centromeres in early mitosis and requires RANBP2.
Di Cesare E, Moroni S, Bartoli J, Damizia M, Giubettini M, Koerner C, Krenn V, Musacchio A, Lavia P.
Cells. 2023 Jan 19;12(3):372. doi: 10.3390/cells12030372. PMID: 36766713; PMCID: PMC9913629More - Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production.
Pellegrini FR, De Martino, Fianco G, Ventura I, Valente D, Fiore M, Trisciuoglio D, Degrassi F.
Autophagy. 2023 Jan 27. doi: 10.1080/15548627.2023.2170962.More - Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells.
Ansari MSZ, Stagni V, Iuzzolino A, Rotili D, Mai A, Del Bufalo D, Lavia P, Degrassi F, Trisciuoglio D
Cancer Gene Ther. 30(1):124-136. doi:10.1038/s41417-022-00524-8.More - The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer.
Masi I, Ottavi F, Del Rio D, Caprara V, Vastarelli C, Giannitelli SM, Fianco G, Mozetic P, Buttarelli M, Ferrandina G, Scambia G, Gallo D, Rainer A, Bagnato A, Spadaro F, Rosanò L.
Cell Death Dis. 2023 Jan 30;14(1):73. doi: 10.1038/s41419-023-05612-7. PMID: 36717550; PMCID: PMC9886921.More - RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G.
Eur J Med Chem. 246:114997. doi: 10.1016/j.ejmech.2022.114997.More
- AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.
- 2022
- Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity.
Rossi F, Beltran M, Damizia M, Grelloni C, Colantoni A, Setti A, Di Timoteo G, Dattilo D, Centrón-Broco A, Nicoletti C, Fanciulli M, Lavia P, Bozzoni I.
Mol Cell. 2022 Jan 6;82(1):75-89.e9. doi: 10.1016/j.molcel.2021.11.032. Epub 2021 Dec 22.PMID: 34942120More
- Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity.
- 2021
- First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D
J Med Chem. 2021 Dec 9;64(23):17031-17050. doi: 10.1021/acs.jmedchem.1c00605. Epub 2021 Nov 29.More - M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines.
Di Bari M, Tombolillo V, Alessandrini F, Guerriero C, Fiore M, Asteriti IA, Castigli E, Sciaccaluga M, Guarguaglini G, Degrassi F, Tata AM.
Cells. 2021 Jul 8;10(7):1727. doi: 10.3390/cells10071727.PMID: 34359896More - PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc.
Boi D, Souvalidou F, Capelli D, Polverino F, Marini G, Montanari R, Pochetti G, Tramonti A, Contestabile R, Trisciuoglio D, Carpinelli P, Ascanelli C, Lindon C, De Leo A, Saviano M, Di Santo R, Costi R, Guarguaglini G, Paiardini A.
Int J Mol Sci. 2021 Dec 4;22(23):13122. doi: 10.3390/ijms222313122.PMID: 34884931More - Prdm16-mediated H3K9 methylation controls Fibro-Adipogenic Progenitors identity during skeletal muscle repair.
Biferali B, Bianconi V, Fernandez Perez D, Pöhle Kronawitter S, Marullo F, Maggio R, Santini T, Polverino F, Biagioni S, Summa V, Toniatti C, Pasini D, Stricker S, Di Fabio R, Chiacchiera F, Peruzzi G, Mozzetta C. 2021.
Sci Adv. 2021 Jun 2;7(23):eabd9371. doi: 10.1126/sciadv.abd9371. PMID: 34078594; PMCID: PMC8172132.More - The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability.
Polverino F, Naso FD, Asteriti IA, Palmerini V, Singh D, Valente D, Bird AW, Rosa A, Mapelli M, Guarguaglini G. 2021.
Curr Biol. 31(3):658-667.e5. Epub 2020 Dec 3.More
- First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
- 2020
- Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.
Verrico A, Rovella P, Di Francesco L, Damizia M, Staid DS, Le Pera L, Schininà ME, Lavia P. 2020.
Oncogene. 39:454-68.More - Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation.
Sardina F, Pisciottani A, Ferrara M, Valente D, Casella M, Crescenzi M, Peschiaroli A, Casali C, Soddu S, Grierson AJ, Rinaldo C. 2020.
Life Sci Alliance. 3(12):e202000799. Print 2020 Dec.More - HIPK2 is required for midbody remnant removal through autophagy-mediated degradation.
Sardina F, Monteonofrio L, Ferrara M, Magi F, Soddu S, Rinaldo C. 2020.
Front Cell Dev Biol. 8:572094.More - Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells.
Di Martile M, Gabellini C, Desideri M, Matraxia M, Farini V, Valentini E,Carradori S, Ercolani C, Buglioni S, Secci D, Andreazzoli M, Del Bufalo D,Trisciuoglio D. 2020.
J Exp Clin Cancer Res. 39(1):103.More - An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis.
Gatti V, Ferrara M, Virdia I, Matteoni S, Monteonofrio L, di Martino S, Diodoro MG, Di Rocco G, Rinaldo C, Soddu S. 2020.
Cells. 9(2):484.More - Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit.
Naso FD, Sterbini V, Crecca E, Asteriti IA, Russo AD, Giubettini M, Cundari E, Lindon C, Rosa A, Guarguaglini G. 2020.
Cells. 9(2):374More - X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics.
Licursi V, Anzellotti S, Favaro J, Sineri S, Carucci N, Cundari E, Fiore M, Guarguaglini G, Pippa S, Nisi PS, Vernì F, Biagioni S, Cacci E, Amendola R, Lupo G, Negri R. 2020.
Sci Rep. 10(1):6562.More - Reverse transcriptase inhibitors promote the remodelling of nuclear architecture and induce autophagy in prostate cancer cells.
Bellisai C, Sciamanna I, Rovella P, Giovannini D, Baranzini M, Pugliese GM, Zeya Ansari MS, Milite C, Sinibaldi-Vallebona P, Cirilli R, Sbardella G, Pichierri P, Trisciuoglio D, Lavia P, Serafino A, Spadafora C. 2020.
Cancer Lett.; 478:133-45.More - The mitotic apparatus and kinetochores in microcephaly and neurodevelopmental diseases.
Degrassi F, Damizia M, Lavia P.
Cells 2019; 9(1):49.More
- Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.
- 2019
- A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin.
Traversi G, Staid DS, Fiore M, Percario Z, Trisciuoglio D, Antonioletti R, Morea V, Degrassi F, Cozzi R. 2019.
Cell Div. 14:3. eCollection 2019.More - HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.
Monteonofrio L, Valente D, Ferrara M, Camerini S, Miscione R, Crescenzi M, Rinaldo C, Soddu S. 2019.
Oncogene. 37:3562-3574.More
- A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin.
- 2018
- Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays.
Di Francesco L, Verrico A, Asteriti IA, Rovella P, Cirigliano P, Guarguaglini G, Schininà ME, Lavia P. 2018.
Sci Rep. 8:1850.More - Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.
Ferrara M., Sessa G., Fiore M., Bernard F., Asteriti I.A., Cundari E., Colotti G., Ferla S., Desideri M., Buglioni S., Trisciuoglio D., Del Bufalo D., Brancale A., Degrassi F. 2018.
Oncogene. 37:231-240.More - New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R. 2018.
Eur J Med Chem. 152:283-297.More
- Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays.
- 2017
- The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.
Traversi G, Fiore M, Percario Z, Degrassi F, Cozzi R. 2017.
Mol Carcinog. 56:1117-26.More - CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.
Barbiero I, Valente D, Chandola C, Magi F, Bergo A, Monteonofrio L, Tramarin M, Fazzari M, Soddu S, Landsberger N, Rinaldo C, Kilstrup-Nielsen C. 2017.
Sci Rep.;7:6228.More - The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme.
Abbruzzese C, Catalogna G, Gallo E, di Martino S, Mileo AM, Carosi M, Dattilo V, Schenone S, Musumeci F, Lavia P, Perrotti N, Amato R, Paggi MG. 2017.
Oncotarget 8:110743-110755.More - Subcellular localization of the five members of the human steroid 5α-reductase family.
Scaglione A, Montemiglio LC, Parisi G, Asteriti IA, Bruni R, Cerutti G, Testi C, Savino C, Mancia F, Lavia P, Vallone B. 2017.
Biochim Open. 4:99-106.More - Importin beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.
Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P. 2017.
J Cell Sci. Jun 9. pii: jcs.197905. [Epub ahead of print]More - Identification of small molecule inhibitors of the Aurora-A/TPX2 complex.
I.A. Asteriti, F. Daidone, G. Colotti, S. Rinaldo, P. Lavia, G. Guarguaglini and A. Paiardini 2017.
Oncotarget, 8:32117-32133.More - PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma.
Colicchia V., Petroni M, Guarguaglini G, Sardina F, Roncero MS, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A and Giuseppe G. 2017.
Oncogene. 36:4682-4691.More - Use of Ferritin-Based Metal-Encapsulated Nanocarriers as Anticancer Agents.
Mosca L., Falvo E., Ceci P., Poser E., Genovese I., Guarguaglini G. and Colotti G. 2017.
Appl. Sci. 7: 101.More - Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.
Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P. 2017
Oncotarget Feb 1.More
- The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis.
- 2016
- RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA.
Del Vecchio G, De Vito F, Saunders SJ, Risi A, Mannironi C, Bozzoni I, Presutti C. 2016.
RNA 22:1510-21.More - Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin.
Sánchez-Lamar A, Piloto-Ferrer J, Fiore M, Stano P, Cozzi R, Tofani D, Cundari E, Francisco M, Romero A, González ML, Degrassi F. 2016.
J Ethnopharmacol. 194:781-8.More - TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure.
De Santis Puzzonia M., Cozzolino A.M., Grassi G., Bisceglia F., Strippoli R., Guarguaglini G., Citarella F., Sacchetti B., Tripodi M., Marchetti A., Amicone L. 2016.
PLoS One. 11:e0167158.More - NuMA phosphorylation by Aurora-A orchestrates spindle orientation.
Gallini S, Carminati M, De Mattia F, Pirovano L, Martini E, Amanda Oldani A, Asteriti IAA, Guarguaglini G, Mapelli M. 2016.
Curr. Biol, 26:458-69More
- RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA.
- 2015
- Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses.
de Turris V, Teloni R, Chiani P, Bromuro C, Mariotti S, Pardini M, Nisini R, Torosantucci A, Gagliardi MC. 2015.
PLoS One. 10:e0142531. eCollection 2015.More - HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.
Valente D, Bossi G, Moncada A, Tornincasa M, Indelicato S, Piscuoglio S, Karamitopoulou ED, Bartolazzi A, Pierantoni GM, Fusco A, Soddu S, Rinaldo C. 2015.
Oncotarget 6:10320-34.More - New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer.
La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R. 2015.
J Med Chem. 58:5789-807.More - Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.
Pierantoni GM, Conte A, Rinaldo C, Tornincasa M, Gerlini R, Federico A, Valente D, Medico E, Fusco A. 2015.
Oncotarget. 6:17342-53More - Amorphous silica nanoparticles alter microtubule dynamics and cell migration.
Gonzalez L, De Santis Puzzonia M, Ricci R, Aureli F, Guarguaglini G, Cubadda F, Leyns L, Cundari E, Kirsch-Volders M. 2015.
Nanotoxicology. 9: 729-36.More
- Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses.
- 2014
- Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability.
Stellas D, Souliotis VL, Bekyrou M, Smirlis D, Kirsch-Volders M, Degrassi F, Cundari E, Kyrtopoulos SA. 2014.
Mutat Res. 769:59-68.More - A N-terminus modified Hec1 suppresses tumor growth by interfering with kinetochore microtubule dynamics.
Orticello M, Fiore M, Totta P, Desideri M, Barisic M, Passeri D, Lenzi J, Rosa A, Orlandi A, Maiato H, Del Bufalo D, Degrassi F. 2015.
Oncogene, 34:3325-35.More - A lower content of de-methylesterified homogalacturonan improves enzymatic cell separation and isolation of mesophyll protoplasts in Arabidopsis.
Lionetti V., Cervone F., De Lorenzo G. 2014.
Phytochemistry, et al : pii: S0031-9422(14)00312-4.More - The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy.
Asteriti I.A., Di Cesare E., De Mattia F., Hilsenstein V., Neumann B., Cundari E., Lavia P., Guarguaglini G. 2014.
Oncotarget 5:6229-42.More - New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
La Regina G., Bai R., Coluccia A., Famiglini V., Pelliccia S., Passacantilli S., Mazzoccoli C., Ruggieri V., Sisinni L., Bolognesi A., Rensen W.M., Miele A., Nalli M., Alfonsi R., Di Marcotullio L., Gulino A., Brancale A., Novellino E., Dondio G.M., Vultaggio S., Varasi M., Mercurio C., Hamel E., Lavia P., Silvestri R. 2014.
J Med Chem.57:6531-52.More - Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization.
Messina G, Damia E, Fanti L, Atterrato MT, Celauro E, Mariotti FR, Accardo MC, Walther M, Vernì F, Picchioni D, Moschetti R, Caizzi R, Piacentini L, Cenci G, Giordano E, Dimitri P. 2014.
J Cell Sci. 127:2577-88.More - Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells.
Guarguaglini G, de Turris V, Lavia P. 2014.
Methods Mol Biol. 1120:241-52.More
- Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability.
- 2013
- The pesticide dichlorvos disrupts mitotic division by delocalizing the kinesin Kif2a from centrosomes.
Fiore M, Mattiuzzo M, Mancuso G, Totta P, Degrassi F. 2013.
Environ Mol Mutagen. 54:250-60.More - Evidence for a common progenitor of epithelial and mesenchymal components of the liver.
Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F, Brenner DA, Kisseleva T, Bianco P, Tripodi M. 2013.
Cell Death Differ. 20:1116-23.More - Reactive oxygen species mediated P. Aeruginosa killing is functional in human CF macrophages.
Cifani N, Pompili B, Anile M, Patella M, Diso D, Venuta F, Cimmino G, Quattrucci S, Di Domenico E, Ascenzioni F, Del Porto P. 2013.
PlosOne, 8:e71717.More
- The pesticide dichlorvos disrupts mitotic division by delocalizing the kinesin Kif2a from centrosomes.
- 2012
- Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio AM, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M. 2012.
PLoS One. 7:e51109.More - HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.
Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S. 2012.
Mol Cell 47:87-98.More - Self-assembling peptide hydrogels promote microglial cells proliferation and NGF production.
Chronopoulou L, Togna AR, Guarguaglini G, Masci G, Giammaruco F, Togna GI and Palocci C. 2012.
Soft matter 8: 5784-5790.More - Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.
Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininà ME, Lavia P. 2012.
J Cell Biol. 196:435-50.More - Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma.
Ooi WF, Re A, Sidarovich V, Canella V, Arseni N, Adami V, Guarguaglini G, Giubettini M, Scaruffi P, Stigliani S, Lavia P, Tonini GP, Quattrone A. 2012.
Genes Chromosomes Cancer 51:545-56.More
- Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
- 2011
- Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces.
Asteriti IA, Giubettini M, Lavia P, Guarguaglini G. 2011.
Mol Cancer 10:131More - Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.
La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, Brancale A, Ferlini C, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Novellino E, Silvestri R. 2011.
J Med Chem. 54:8394-406.More - Control of Aurora-A stability through interaction with TPX2.
Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P and Guarguaglini G. 2011.
J Cell Sci. 124:113-22.More
- Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces.
- 2010
- Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.
Ciciarello M, Roscioli E, Di Fiore B, Di Francesco L, Sobrero F, Bernard D, Mangiacasale R, Harel A, Schininà ME and Lavia P. 2010.
Chromosoma 119:651-68.
- Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.